Table of Contents
Part I: the Analytical Problem
Investigation 1: Properties of Danshen's Constituent Compounds
Part II: Separating and Analyzing Mixtures Using HPLC with UV Detection
Investigations 2–3: Reverse-Phase HPLC and Order of Elution of Solutes
Investigations 4–6: UV Detection and Beer's Law
Part III: Extracting Analytes from Samples
Investigations 7–9: Solvent Extraction of Danshen
Part IV: Optimizing the Solvent, Temperature, and Microwave Power
Investigation 10: One-Factor-at-a-Time Experimental Optimizations
Investigations 11–13: Optimizing the Solvent (Part A)
Investigation 14: Optimizing the Solvent (Part B)
Investigation 15: Optimizing the Temperature (Part A)
Investigation 16: Optimizing the Temperature (Part B)
Investigation 17: Optimizing the Microwave's Power (Part A)
Investigation 18: Optimizing the Microwave's Power (Part B)
Part V: Optimizing the Solid-to-Solution Ratio and the Extraction Time
Investigations 19–21: Optimizing Two Factors at Once Using a Central-Composite Design
Investigations 22–23: Modeling the Effect of Solid-to-Solution Ratio and Extraction Time on Extraction Yield of Danshensu
Investigations 24–25: Modeling the Effect of Solid-to-Solution Ratio and Extraction Time on Extraction Yields of Other Analytes
Part VI: Findng the Global Optimum Across all Analytes
Investigation 26: Individual Desirability Functions
Investigations 27–29: The Global Desirability Function and the Total Extraction of Danshen
Part VII: Verifying the Analytical Method's Accuracy
Investigation 30: Extraction Yield for Danshensu
Investigation 31: Extraction Yields for Other Analytes
Investigation 32: Comparing Results to Other Analytical Methods
Investigation 33: Spike-Recovery Studies
Part VIII: Applying the Analytical Method
Investigation 34: Analysis of Wild and Cultivated Samples of Danshen
Part IX: Summary of case study
Closing Thoughts
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