Possible Genes

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 Possible Other Genes Linked to Multiple Sclerosis:
Candidate Gene
(Updated May 2002)		 Chromosomal Location Study Design Representative References
Glutathione S-transferase mu 1p13.3 case-control Mann, 2000
Interleukin-12 receptor beta 2 1p31 family-based Reboul, 2000
T cell specific adapter protein (TDAd) 1q21 case-control Dai, 2001
Fas Ligand 1q23 case-control Zayas, 2001
Interleukin 10 1q31-q32 family-based He, 1997; Reboul, 2000
Interleukin 10 1q31-q32 case-control He, 1997; Pickard, 1999; Maurer, 2000
Protein tyrosine phosphatase receptor type C (CD45) 1q31-32 family-based Barcellos, 2001
Protein tyrosine phosphatase receptor type C (CD45) 1q31-32 case-control Jacobsen, 2001
Transforming growth factor (TGF) B2 1q31 family-based He, 1997; Mertens, 1998
Transforming growth factor (TGF) B2 1q31 case-control He, 1997; McDonnell, 1999
HRES-1 retro-element 1q32-q42 case-control Rasmussen, 1997; Rasmussen, 2000
Transforming growth factor BR3 1p32-p33 family-based Mertens, 1998
Rhesus blood group 1p36.2-p34 case-control Roberts, 1979
Apolipoprotein (APO) B 2p23-24 family-based Chataway, 1999a
Interleukin 1 receptor antagonist/ interleukin-1B (IL-1ra/IL-1b) 2q14.2 family-based Wansen, 1997; Semana, 1997; Schrijver, 1999; Feakes, 2000
Interleukin 1 receptor antagonist/ interleukin-1B (IL-1ra/IL-1b) 2q14.2 case-control Crusius, 1995; Wansen, 1997; Semana, 1997; de la Concha, 1997; McDonnell, 2000
Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) 2q33 case-control Harbo, 1999; Ligers, 1999; Fukazawa, 2000 Rasmussen, 2001; Dyment, 2002
Erb-B4 2q34 family-based Mertens, 1998
Natural resistance-associated macrophage protein-1 (NRAMP1) 2q35 case-control Kotze, 2001
Chemokine receptor 5 (CCR5) 3p21 case-control Bennetts, 1997
Transforming growth factor BR2 3p22 family-based Mertens, 1998
B7-1 3q13.3-q21 Case-control Weinshenker, 2000
Interleukin 12p35 3q25-q26.2 family-based Reboul, 2000
Fibroblast growth factor Re 4p16.3 family-based Mertens, 1998
Platelet derived growth factor Ra 4q11-q12 family-based Mertens, 1998
Vitamin D binding protein 4q12 family-based Reboul, 2000
Fibroblast growth factor 2 4q25-q27 family-based Mertens, 1998
Interleukin 2 4q26-q27 family-based He, 1997; Reboul, 2000; Feakes, 2000
Interleukin 2 4q26-q27 case-control He, 1997; McDonnell, 2000
Microtubule associated protein 1B 5q13 family-based Chataway, 1999
Interleukin 4 5q23-31 family-based He, 1997; Reboul, 2000
Interleukin 4 5q23-31 case-control Vandenbroeck, 1997; He, 1997; McDonnell, 2000
Interleukin 9 5q23-31 case-control McDonnell, 2000
Fibroblast growth factor 1 5q31.3-q33.2 family-based Mertens, 1998
Interferon regulatory factor 1 (IRF1) 5q31 family-based Vandenbroeck, 2000
Interleukin 12p40 5q33 family-based Reboul, 2000
Pc 1 Duarte 6p21 case-control Comings, 1979
HLA-DR 6p21.3 family-based Haines, 1998
HLA-DR 6p21.3 case-control Seboun, 1996 (review)
HLA-DQ 6p21.3 case-control Seboun, 1996 (review)
HLA-DP 6p21.3 case-control Fugger, 1990
HLA-DM 6p21.3 case-control Ristori, 1997
HLA-DRA promoter 6p21.3 Case-control Bennetts, 1999
Complement C4/CYP21 6p21.3 case-control Franciotta, 1995
Tumor necrosis factor alpha 6p21.3 case-control Garcia-Merino, 1996; Huizinga, 1997; Fernandez-Arquero, 1999
Transporters associated with antigen processing 6p21.3 case-control Liblau, 1993; Spurkland, 1994; Bell, 1995
Myelin oligodendrocyte glycoprotein (MOG) 6p21.3 case-control Hilton, 1995; Roth, 1995; Rodriguez, 1997
Myelin oligodendrocyte glycoprotein (MOG) 6p21.3 family-based Seboun, 1999
Heat shock protein 70 6p21.3 case-control Ramachandran, 1995; Cascino, 1994
Interferon gamma receptor 1 6q23-q24 family-based Reboul, 2000
Estrogen receptor a 6q25.1 case-control Niino, 2000
Erb-B 7p12 family-based Mertens, 1998
Interleukin 6 7p15-p21 case-control Schmidt, 2000
Platelet derived growth factor a 7p22 family-based Mertens, 1998
Plasminogen activator inhibitor 1 7q22-31 Case-control Luomala, 2000
T cell antigen receptor (TCR) B 7q35 family-based Seboun, 1989; Lynch, 1991; Wansen, 1997; Hockertz, 1998
T cell antigen receptor (TCR) B 7q35 case-control Beall, 1989; Fugger, 1990; Epplen, 1997; Wansen, 1997; Buhler, 2000
ERV3 retro-element 7 case-control Rasmussen, 1996
Fibroblast growth factor R1 8p12 family-based Mertens, 1998
Glial growth factor 8p21 family-based Mertens, 1998
Interferons alpha/beta 9p21 family-based Bergkvist, 1996
Interferons alpha/beta 9p21 case-control Miterski, 1999
Transforming growth factor BR1 9q33-q34 family-based Mertens, 1998
Interleukin-2R alpha 10p15 family-based Reboul, 2000
Fas Apo-1 antigen 10q24.1 case-control Cascino, 1998; Huang, 2000
Fibroblast growth factor BR2 10q25.3-q26 family-based Mertens, 1998
Ciliary neurotrophic factor (CNTF) 11q22.2 case-control Giess, 2002; Hoffmann, 2002
Interleukin-10 receptor 11q23.3 family-based Reboul, 2000
Glutathione S-transferase pi 11 case-control Mann, 2000
Interleukin 12p40 (IL12b) 11 case-control Van Veen, 2001
Neurotrophin-3 12p13 family-based Mertens, 1998
Alpha-2-macroglobulin (A2M) 12p13.3 case-control Schweer, 2001
Erb-B3 12p family-based Mertens, 1998
Vitamin D receptor 12q13-q14 family-based Steckley, 2000
Vitamin D receptor 12q13-q14 case control Fukazawa, 1999
Low-density lipoprotein receptor (LRP) 12q13-q14 case-control Schweer, 2001
25(OH)D3 1 alpha-hydroxilase 12q13 family-based Steckley, 2000
Interferon gamma 12q14-15 family-based Wansen, 1997; He, 1997; Dai, 2001
Interferon gamma 12q14-15 case-control Wansen, 1997; He, 1997; Goris, 1999
Spinocerebellar ataxia 2 (SAC2) 12q21-23 case-control Miterski, 2000
Insulin-like growth factor 1 12q23 family-based Mertens, 1998
Nitric oxide synthase (NOS1) 12q24.2-24.31 family-based Xu, 1999
T cell antigen receptor (TCR) A/D 14q11.2 family-based Lynch, 1992
T cell antigen receptor (TCR) A/D 14q11.2 case-control Oksenberg, 1989; Hashimoto, 1992
Transforming growth factor B3 14q24 family-based Mertens, 1998
Immunoglobulin G heavy chain 14q32 family-based Wansen, 1997; Wood, 1995
Immunoglobulin G heavy chain 14q32 case-control Wansen, 1997
Immunoglobulin constant region 14q32 case-control Gaiser, 1987
Immunoglobulin variable region 14q32 family-based Hashimoto, 1993; Ligers, 1997; Feakes, 2000
Immunoglobulin variable region 14q32 case-control Walter, 1991
Alpha-1 antitrypsin 14q24 case-control McCombe, 1985
Insulin-like growth factor 1R 15q25-qter family-based Mertens, 1998
TRK-C 15q24-q25 family-based Mertens, 1998
Interleukin 4 receptor 16p12.1-p11.2 family-based He, 1997; Reboul, 2000
Interleukin 4 receptor 16p12.1-p11.2 case-control He, 1997; Hackstein, 2001
MHC Class II transactivator 16p13 case-control Rasmussen, 2001
2'3'-cyclic nucleotide 3'-phosphodiesterase 17q21 family-based Thompson, 1996; He, 1997, Chataway, 1999a
2'3'-cyclic nucleotide 3'-phosphodiesterase 17q21 case-control Thompson, 1996; He, 1997
Myeloperoxidase 17q23.1 case-control Nagra, 1997; Nelissen, 2000 (b)
Myeloperoxidase 17q21.3-23.1 family-based Chataway, 1999 (a); Nelissen, 2000 (b)
RIalpha of cAMP-dependent protein kinase (PRKAR1A) 17q21-q24 case-control Nelissen, 2000 (b)
RIalpha of cAMP-dependent protein kinase (PRKAR1A) 17q21-q24 family-based Nelissen, 2000 (b)
phenylethanolamine N-methyltransferase 17q21-q22 case-control Mann, 2002
Apoplipoprotein (APO) H 17q22 family-based Chataway, 1999 (a); Nelissen, 2000 (b)
Platelet/endothelial cell adhesion molecule (PECAM-1) 17q23 case-control Sciacca, 2000; Nelissen, 2000 (b)
Monocyte chemotactic protein (MCP)-3 17q11.2 case-control Fiten, 1999
Oligodendrocyte myelin glycoprotein (OMGP) 17q11.2 family-based He, 1997; Seboun, 1999
Oligodendrocyte myelin glycoprotein (OMGP) 17q11.2 case-control Hinks, 1995; He, 1997
Erb-B2 17q11.2 family-based Mertens, 1998
Ecotropic viral integration 17q11 case-control Hinks, 1995
Myelin basic protein (MBP) 18q22-qter case-control Boylan, 1991; Tienari, 1992; Ibsen, 1996
Myelin basic protein (MBP) 18q22-qter family-based Tienari, 1998; Choppin, 2001
Third component of complement (C3) 19p13-tel case-control Bernal, 1986; Bulman, 1991
Intracellular adhesion molecule 1 (ICAM-1) 19p13.3-p13.2 case-control Mycko, 1998; Luomala, 1999
Notch3 19p13.2-p13.1 Family-based Broadley, 2001
Apolipoprotein (APO) E 19q13 case-control Rubinsztein, 1994; Gaillard, 1998; Evangelou, 1999; Olivery, 1999; Chapman, 2000; Weatherby, 2000; Chapman, 2001; Fazekas, 2001
Apolipoprotein (APO) E 19q13 family-based Schmidt, 2002
Myelin associated glycoprotein (MAG) 19q13.1 family-based He, 1997; Seboun, 1999; Chataway, 1999a
Myelin associated glycoprotein (MAG) 19q13.1 case-control He, 1997
Interleukin-12 receptor beta 1 19q13 family-based Reboul, 2000
Transforming growth factor (TGF)B1 19q13 case-control He, 1997; McDonnell, 1999; Weinshenker, 2001
Transforming growth factor (TGF)B1 19q13.2 family-based He, 1997; Mertens, 1998
Apolipoprotein (APO) C-II 19q13.2 case-control Zouali, 1999
Apolipoprotein (APO) C-II 19q13.2 family-based Chataway, 1999a
Gelatinase B 20q11.2-q13.1 family based Nelissen, 2000
Gelatinase B 20q11.2-q13.1 case-control Nelissen, 2000
Interferon gamma receptor 2 21q22.1 family-based Reboul, 2000
Tissue inhibitor of metalloproteinase 3 (TIMP3) 22q12 family-based Chataway, 1999a
Neurofibromatosis 2 (NF2) 22q12 family-based Chataway, 1999
Platelet-derived growth factor B 22q12.3-q13.1 family-based Mertens, 1998
CYP2D6 22q13 case-control Agundez, 1995
Interleukin-2 receptor beta 22q13 case-control McDonnell, 2000
Glutathione S-transferase theta 22 case-control Mann, 2000
Interleukin-2R gamma Xq13.1 family-based Reboul, 2000
Gamma-aminobutyric acid A3 R Xq22-q28 case-control Gade-Andavolu, 1998
Proteolipid protein (PLP) Xq22 family-based He, 1997; Seboun, 1999
Proteolipid protein (PLP) Xq22 case-control Price, 1997 He, 1997
CD40 ligand Xq26 case-control Dai, 2002
Spino-cerebellar ataxias-related CAG repeats 3p, 6p, 11, 12q, 14q, 19p family-based Chataway, 1999 (b)
Mitochondrial sequences case-control Kellar-Wood, 1994; Kalman, 1996; Kalman, 1998
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